Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter in the central nervous system which is a key target of pharmaceutical drugs in the treatment of anxiety and other conditions. A review of clinical trials shows that a number of herbs traditionally used for anxiety are 1) clinically effective compared to placebo or the pharmaceuticals 2) have effects on the GABA system and 3) do not present the side effects common with the pharmaceuticals. For each of the herbs, in addition to a long history of traditional use and abundant contemporary experience, we have preclinical studies in-vitro and in-vivo showing effects on GABA receptors, and human clinical studies showing a positive effect on anxiety. The clinical trials collectively present innovative methods for dosing strategies, and duration to obtain results. Herbs we will cover include Matricaria, Passiflora, Scutellaria, Melissa, Centella, Ocimum, Piper meth, Valeriana, and Humulus.